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Yoshihiro Hasegawa Selected Research

N- (3,4- dimethoxyphenethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamide

12/2010(E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice.
1/2010TJN-331 improves anti-glomerular basement membrane nephritis by inhibiting the production of intraglomerular transforming growth factor-beta1.
1/2010Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming growth factor-β1 production.

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Yoshihiro Hasegawa Research Topics

Disease

11Neoplasms (Cancer)
12/2023 - 07/2002
5Prostatic Neoplasms (Prostate Cancer)
09/2014 - 07/2002
5Renal Cell Carcinoma (Grawitz Tumor)
12/2010 - 10/2007
3Inflammation (Inflammations)
11/2012 - 02/2011
3Fatigue
05/2012 - 03/2010
3Nephritis
02/2011 - 01/2010
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2022 - 01/2013
2Infections
01/2017 - 11/2012
2Glomerulonephritis
02/2011 - 01/2010
2IGA Glomerulonephritis (IGA Nephropathy)
12/2010 - 10/2009
2Hand-Foot Syndrome
12/2010 - 03/2010
2Adenocarcinoma
01/2010 - 01/2009
1Silicosis
02/2023
1Fibrosis (Cirrhosis)
02/2023
1Pneumonia (Pneumonitis)
02/2023
1Lung Injury
02/2023
1Pulmonary Fibrosis (Fibrosing Alveolitis)
02/2023
1Lung Diseases (Lung Disease)
01/2023
1Pulmonary Alveolar Microlithiasis
01/2023
1Abscess
03/2022
1Carcinogenesis
01/2022
1Adenocarcinoma of Lung
11/2017
1Disease Progression
10/2017
1Idiopathic Pulmonary Fibrosis
10/2017
1Schistosomiasis (Bilharziasis)
02/2014
1Breast Neoplasms (Breast Cancer)
11/2013
1Amyloidosis
10/2013
1Urinary Retention
06/2013
1Neoplasm Metastasis (Metastasis)
05/2012
1Hypertension (High Blood Pressure)
03/2010

Drug/Important Bio-Agent (IBA)

4Proteins (Proteins, Gene)FDA Link
01/2023 - 10/2009
3EnzymesIBA
01/2023 - 10/2009
3N- (3,4- dimethoxyphenethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamideIBA
12/2010 - 01/2010
2Polysaccharides (Glycans)IBA
12/2023 - 11/2014
2Monoclonal AntibodiesIBA
02/2023 - 01/2013
2Pulmonary Surfactant-Associated Protein A (Surfactant Protein A)IBA
11/2017 - 01/2017
2Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
10/2017 - 11/2012
2Neuregulin-1 (Neuregulin 1)IBA
11/2014 - 11/2013
2Transforming Growth Factors (Transforming Growth Factor)IBA
02/2011 - 10/2009
2Sunitinib (Sutent)FDA Link
12/2010 - 03/2010
2Lipase (Acid Lipase)FDA Link
12/2010 - 03/2010
2CarbonIBA
12/2010 - 10/2009
2Transforming Growth Factor beta1 (TGF beta 1)IBA
01/2010 - 10/2009
1ErbB Receptors (EGF Receptor)IBA
12/2023
1tyrosine receptor (receptor, tyrosine)IBA
12/2023
1Phosphotransferases (Kinase)IBA
12/2023
1LigandsIBA
02/2023
1Cytokine Receptors (Cytokine Receptor)IBA
02/2023
1RNA (Ribonucleic Acid)IBA
02/2023
1Peptide Hydrolases (Proteases)FDA Link
02/2023
1Silicon Dioxide (Silica)FDA LinkGeneric
02/2023
1Hydrochloric Acid (Hydrogen Chloride)FDA Link
02/2023
1sodium phosphate (trisodium phosphate)FDA LinkGeneric
01/2023
1calcium phosphateIBA
01/2023
1SymportersIBA
01/2023
1Durapatite (Hydroxylapatite)IBA
01/2023
1Phosphates (Orthophosphate)IBA
01/2023
1LipidsIBA
01/2023
1Tyrosine Kinase InhibitorsIBA
04/2022
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
04/2022
1Anti-Bacterial Agents (Antibiotics)IBA
03/2022
1Ribosomal DNA (rDNA)IBA
03/2022
1GlycosyltransferasesIBA
01/2022
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2022
1Calmodulin-Binding Proteins (Caldesmon)IBA
01/2019
1DesminIBA
01/2019
1Epidermal Growth Factor (EGF)IBA
11/2017
1pirfenidoneIBA
10/2017
1Praziquantel (Biltricide)FDA Link
02/2014
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
10/2013
1Serum Amyloid A Protein (Serum Amyloid A)IBA
10/2013
1Prostate-Specific Antigen (Semenogelase)IBA
06/2013
1GangliosidesIBA
01/2013
1N-glycolylneuraminic acidIBA
01/2013
1LectinsIBA
11/2012
1Uroplakin IaIBA
11/2012
1Messenger RNA (mRNA)IBA
11/2012
1Glycoproteins (Glycoprotein)IBA
11/2012
1Indicators and Reagents (Reagents)IBA
04/2012
1N- (2- (3,4- dimethoxyphenyl)- 2- oxoethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamideIBA
02/2011
1RolipramIBA
02/2011
1anti-Thy antibodyIBA
02/2011
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2011
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
02/2011
1CytokinesIBA
12/2010
1GlobulinsIBA
12/2010
1Drinking WaterIBA
01/2010
1antiglomerular basement membrane antibodyIBA
01/2010
1Interleukin-12 (IL 12)IBA
01/2010

Therapy/Procedure

9Therapeutics
02/2023 - 04/2009
5Prostatectomy (Retropubic Prostatectomy)
03/2013 - 07/2002
5Nephrectomy
05/2012 - 10/2007
3Drug Therapy (Chemotherapy)
12/2023 - 04/2005
3Oral Administration
12/2010 - 10/2009
2Lymph Node Excision (Lymph Node Dissection)
05/2012 - 11/2005
2Radiofrequency Ablation
05/2012 - 10/2007
2Immunotherapy
05/2012 - 06/2009
1Occlusive Dressings (Occlusive Dressing)
10/2013
1Intravenous Administration
12/2010
1Intravenous Injections
01/2010